Literature Review: Manfaat Tradisional, Kandungan Fitokimia, Aktivitas Farmakologis, dan Potensi Pengembangan Sediaan Antibakteri dari Tumbuhan Kakao (Theobroma cacao L.)

Agaphe Suluh Brahmantio; Ramadhan Triyandi; Zulpakor Oktoba; Femmy Andrifianie; Muhammad Iqbal

doi:10.62027/praba.v3i2.362

Authors

Agaphe Suluh Brahmantio Universitas Lampung
Ramadhan Triyandi Universitas Lampung
Zulpakor Oktoba Universitas Lampung
Femmy Andrifianie Universitas Lampung
Muhammad Iqbal Universitas Lampung

DOI:

https://doi.org/10.62027/praba.v3i2.362

Keywords:

Antibacterial, Phytochemicals, Formulation, Cacao

Abstract

The cacao plant (Theobroma cacao L.) has long been used in traditional medicine and has been proven to contain phytochemical compounds such as polyphenols, flavonoids, alkaloids, and tannins, which exhibit pharmacological activities, including antioxidant, anti-inflammatory, and antibacterial properties. This study aims to review the potential development of antibacterial formulations based on cacao extract through a literature review. The method used is a qualitative descriptive analysis of national and international journals published in the last 10 years. The review results indicate that extracts from cacao seeds, fruit peels, and leaves are effective in inhibiting the growth of various pathogenic bacteria, both Gram-positive and Gram-negative. Various formulations such as gels, creams, lotions, soaps, toothpaste, and mouthwash have been developed with promising results. The utilization of the cacao plant as an antibacterial agent in pharmaceutical formulations holds great potential as a natural alternative in the healthcare field while also adding value to cocoa industry by-products.

References

Abellera, C. A. V., Fiscal, R. R., & Mesina, S. P. (2019). Ethnopharmacological survey of medicinal plants used in treating skin diseases in the Province of Laguna, Philippines. Asia Pacific Journal of Multidisciplinary Research, 7, 88–95.

Abulude, F. O., Fadipe, V. O., Adetuberu, A. A., Ojo, O. F., & Omoboyowa, D. A. (2022). Phytochemical assessment of the extracts of stem (bark) and leaves of Theobroma cacao materials: Experimental procedure and its comparison to literature. ASEAN Journal for Science and Engineering in Materials, 1(2), 85–92.

Adi-Dako, O., Ofori-Kwakye, K., Frimpong Manso, S., Boakye-Gyasi, M. E., Sasu, C., & Pobee, M. (2016). Physicochemical and antimicrobial properties of cocoa pod husk pectin intended as a versatile pharmaceutical excipient and nutraceutical. Journal of Pharmaceutics, 2016, Article 7608693. https://doi.org/10.1155/2016/7608693

Anastasia, A., Yuliet, Y., & Tandah, M. R. (2017). Formulasi sediaan mouthwash pencegah plak gigi ekstrak biji kakao (Theobroma cacao L.) dan uji efektivitas pada bakteri Streptococcus mutans. Jurnal Farmasi Galenika, 3(1), 84–92.

Anoraga, S. B., Shamsudin, R., Hamzah, M. H., Sharif, S., & Saputro, A. D. (2024). Cocoa by-products: A comprehensive review on potential uses, waste management, and emerging green technologies for cocoa pod husk utilization. Heliyon, 10, Article eXXXXXX. https://doi.org/10.1016/j.heliyon.2024.XXXXX (Lengkapi jika tersedia)

Atikah, A. R., Budi, H. S., & Kusumaningsih, T. (2016). Antibacterial effect of 70% ethanol and water extract of cacao beans (Theobroma cacao L.) on Aggregatibacter actinomycetemcomitans. Dental Journal (Majalah Kedokteran Gigi), 49(2), 104–109.

Badan Pusat Statistik. (2024). Statistik Kakao Indonesia: Volume 8. BPS-Statistics Indonesia.

Cerri, M., Reale, L., & Zadra, C. (2019). Metabolite storage in Theobroma cacao L. seed: Cyto-histological and phytochemical analyses. Frontiers in Plant Science, 10, Article 1599. https://doi.org/10.3389/fpls.2019.01599

Chusniasih, D., & Tutik, T. (2021). Identification phytochemical compound of ethanol and acetone extract of cocoa pods (Theobroma cacao L.) using GC-MS. Journal of Physics: Conference Series, 1882(1), 012103. https://doi.org/10.1088/1742-6596/1882/1/012103

Cura, J. K., Basilio, A., & Llagas, M. C. D. L. (2021). Antidiabetic, anti-inflammatory and cytotoxic potential of Theobroma cacao Linn. husk aqueous extracts. Clinical Phytoscience, 7, Article 34. https://doi.org/10.1186/s40816-021-00287-z

Dillinger, T. L., Barriga, P., Escárcega, S., Jimenez, M., Lowe, D. S., & Grivetti, L. E. (2000). Food of the gods: Cure for humanity? A cultural history of the medicinal and ritual use of chocolate. The Journal of Nutrition, 130(8), 2057S–2072S.

Ebuehi, O. A., Anams, C., Gbenle, O. D., & Ajagun‐Ogunleye, M. O. (2019). Hydro‐ethanol seed extract of Theobroma cacao exhibits antioxidant activities and potential anticancer property. Journal of Food Biochemistry, 43(4), e12767. https://doi.org/10.1111/jfbc.12767

Fajardo, J. G. B., Tellez, H. B. H., Atuesta, G. C. P., Aldana, A. P. S., & Arteaga, J. J. M. (2022). Antioxidant activity, total polyphenol content and methylxanthine ratio in four materials of Theobroma cacao L. from Tolima, Colombia. Heliyon, 8(5), e09245. https://doi.org/10.1016/j.heliyon.2022.e09245

Fathima, A., & Rao, J. R. (2016). Selective toxicity of catechin—A natural flavonoid towards bacteria. Applied Microbiology and Biotechnology, 100, 6395–6402. https://doi.org/10.1007/s00253-016-7514-9

García-Flores, J., González-Espinosa, M., Lindig-Cisneros, R., & Casas, A. (2019). Traditional medicinal knowledge of tropical trees and its value for restoration of tropical forests. Botanical Sciences, 97(3), 336–354. https://doi.org/10.17129/botsci.2287

Hasanuddin, A., Anwar, K., & Mappatoba, M. (2019). Antibacterial and antioxidant activities of ethanol extracts of cocoa husk (Theobroma cacao L.) with maltodextrine in various concentrations. IOP Conference Series: Earth and Environmental Science, 255(1), 012017. https://doi.org/10.1088/1755-1315/255/1/012017

Hikmawanti, N. P., Widiyarti, G., & Sugihartini, N. (2023). Formulasi dan uji stabilitas sediaan krim ekstrak kulit biji kakao (Theobroma cacao L.). Jurnal Ilmu Kefarmasian Indonesia, 21(2), 171–180. https://doi.org/10.35814/jifi.v21i2.4325

Kakati, N., Das, A. J., Goswami, P., & Yadav, R. N. S. (2014). Anti-inflammatory effect of Theobroma cacao by inhibition of COX-2 and TNF-α expression in carrageenan induced mice model. International Journal of Pharmacy and Pharmaceutical Sciences, 6(1), 436–440.

Kasuma, R., Muharni, M., & Fitriani, A. (2020). Aktivitas antibakteri ekstrak metanol kulit biji kakao (Theobroma cacao L.) terhadap Staphylococcus aureus dan Propionibacterium acnes. Jurnal Farmasi Higea, 12(2), 68–73.

Kementerian Pertanian Republik Indonesia. (2022). Statistik Perkebunan Kakao 2020–2022. Direktorat Jenderal Perkebunan. https://ditjenbun.pertanian.go.id

Kurniawan, A., Yuliet, Y., & Anastasia, A. (2020). Aktivitas antibakteri sediaan krim ekstrak etanol biji kakao (Theobroma cacao L.) terhadap Staphylococcus aureus dan Propionibacterium acnes. Jurnal Farmasi Galenika, 6(1), 39–46.

La Torre, A., Mandalà, C., & Battaglia, V. (2021). Cocoa diseases: A review of old and emergent pathogens and their impact on the chocolate industry. Plants, 10(6), Article 1208. https://doi.org/10.3390/plants10061208

Mahmood, N. D., Nasir, N. L. M., Rofiee, M. S., Tohid, S. F. M., Ching, S. M., … & Zakaria, Z. A. (2014). Amelioration of paracetamol-induced hepatotoxicity in rats via the administration of methanolic extract of Theobroma cacao leaves. Drug Design, Development and Therapy, 8, 1315–1327. https://doi.org/10.2147/DDDT.S61770

Martoyo, T. (2013). Tumbuhan obat tradisional Indonesia: Khasiat dan kegunaannya dalam kehidupan sehari-hari. Kanisius.

Muchtaridi, M., Diantini, A., & Subarnas, A. (2011). Natural flavonoids as antihistamines: A review of the literature. Pharmaceutical Sciences, 17(1), 1–9. https://doi.org/10.24099/ps.2011.1.001

Mutmainnah, D., & Wardhani, R. S. A. (2017). The effect of cacao (Theobroma cacao L.) extract cream against skin aging due to ultraviolet rays exposure. Pharmaceutical Sciences and Research, 4(3), 143–149. https://doi.org/10.7454/psr.v4i3.3546

Nanditha, V., Kiranmayi, P., & Rohini, K. (2023). Review on Theobroma cacao (cocoa) as a potential drug. International Journal of Pharmacy and Pharmaceutical Research, 27(1), 101–109. https://doi.org/10.53555/ijppr.v27i1.2517

Nurcholis, W. (2020). Efektivitas ekstrak kulit buah kakao (Theobroma cacao L.) terhadap pertumbuhan bakteri Staphylococcus aureus. Jurnal Agroteknika, 13(2), 82–89.

Nurhayati, A., & Pangestuti, A. R. (2021). Identifikasi senyawa metabolit sekunder ekstrak kulit biji kakao (Theobroma cacao L.) menggunakan GC-MS. Jurnal Farmasi Galenika, 7(2), 169–175.

Prabawati, A. I., & Sulastri, D. (2023). Review: Pemanfaatan kulit buah kakao (Theobroma cacao L.) sebagai bahan aktif dalam sediaan topikal untuk perawatan jerawat. Jurnal Farmasi Indonesia, 20(1), 50–58. https://doi.org/10.32583/jfi.v20i1.3192

Putri, D. A., & Herowati, R. (2020). Formulasi dan uji stabilitas sediaan gel ekstrak biji kakao (Theobroma cacao L.) sebagai antiacne. Jurnal Fitofarmaka Indonesia, 7(2), 145–151.

Rizki, D. R., Isnugroho, R. A., & Pratiwi, A. N. (2021). Identifikasi dan uji aktivitas antibakteri senyawa aktif dari ekstrak etanol kulit buah kakao (Theobroma cacao L.). Pharmacon: Jurnal Farmasi Indonesia, 18(2), 145–150. https://doi.org/10.23917/pharmacon.v18i2.13870

Sari, K., & Azim, M. R. (2022). Uji aktivitas antibakteri dan identifikasi senyawa aktif ekstrak etanol kulit buah kakao (Theobroma cacao L.). Jurnal Penelitian Sains, 25(2), 50–58.

Setiawan, H., Wibowo, M. A., & Lestari, D. (2021). Formulasi sediaan krim ekstrak kulit biji kakao (Theobroma cacao L.) dan uji efektivitas terhadap bakteri penyebab jerawat. Jurnal Ilmu Kefarmasian Indonesia, 19(1), 12–20. https://doi.org/10.35814/jifi.v19i1.2321

Sipayung, H. L., Simanjuntak, P., & Sihotang, E. (2022). Pengaruh penggunaan ekstrak kulit biji kakao (Theobroma cacao L.) terhadap aktivitas antibakteri Propionibacterium acnes. Jurnal Farmasi Sains dan Praktis, 8(1), 33–39. https://doi.org/10.25077/jfsp.8.1.33-39.2022

Susilowati, R., & Handayani, D. (2019). Potensi antioksidan dari kulit biji kakao (Theobroma cacao L.). Jurnal Kimia dan Pendidikan Kimia, 4(2), 67–73.

Tati, A. K., Juarna, J., & Alatas, F. (2020). Evaluasi formulasi sediaan gel ekstrak kulit buah kakao (Theobroma cacao L.) sebagai antibakteri terhadap Staphylococcus aureus. Jurnal Farmasi dan Ilmu Kefarmasian Indonesia, 7(1), 20–28. https://doi.org/10.20473/jfiki.v7i1.2020.20-28

Utami, R., & Hidayat, T. (2023). Review: Potensi ekstrak kulit biji kakao (Theobroma cacao L.) dalam pengembangan sediaan topikal sebagai antiinflamasi dan antiacne. Jurnal Riset Kefarmasian Indonesia, 3(2), 75–84.

Wahyuni, D., & Fitria, L. (2021). Aktivitas antioksidan ekstrak kulit biji kakao (Theobroma cacao L.) menggunakan metode DPPH. Jurnal Ilmiah Farmasi, 10(1), 40–46. https://doi.org/10.23917/jif.v10i1.13245

Widowati, W., Wibowo, S., & Fauziah, N. (2016). Cocoa flavonoid as anti-aging and antioxidant in cellular models. Asian Journal of Pharmaceutical and Clinical Research, 9(4), 75–79.

Yanti, N. A., & Ramadani, D. (2020). Uji aktivitas antibakteri dan penetapan senyawa fenolik total dari ekstrak etanol kulit biji kakao (Theobroma cacao L.). Jurnal Fitofarmaka Indonesia, 7(2), 172–177.

Yuliana, R., & Nurfarida, I. (2018). Uji stabilitas fisik sediaan krim ekstrak kulit biji kakao (Theobroma cacao L.) sebagai antiacne. Jurnal Farmasi Galenika, 4(1), 55–62.