Efek Imunomodulator Ginseng (Panax sp.) terhadap Sistem Imun Tubuh: Tinjauan Sistematis
DOI:
https://doi.org/10.62027/vitamedica.v3i2.347Keywords:
Ginseng, Immunomodulator, Immunomodulatory Effect, Immune SystemAbstract
Ginseng strengthens the body's resistance to disease through its effects on components of the immune system. This study aims to examine the immunomodulatory effects of ginseng (Panax sp.) in relation to its active ingredients and constituents that are beneficial to the immune system. This research is a systematic review conducted based on PRISMA items. Literature was searched through the PubMed, ScienceDirect, and Google Scholar databases, covering publications from 2020 to 2025. A total of 523 articles were collected from the three databases. Based on screening and analysis using PRISMA items, 6 articles met the inclusion and exclusion criteria. Ginseng may act as an immunomodulatory agent in the immune system, with various benefits derived from its active compounds.
References
Ardiningtyas, S. A., & Arista, N. I. D. (2023). Kajian metabolit sekunder tanaman ginseng Korea dan Indonesia sebagai peningkat imun tubuh. Holistic: Journal of Tropical Agriculture Sciences, 1(1). https://doi.org/10.61511/hjtas.v1i1.2023.244
Chen, H., Li, X., Chi, H., Li, Z., Wang, C., Wang, Q., Feng, H., & Li, P. (2024). A qualitative analysis of cultured adventitious ginseng root’s chemical composition and immunomodulatory effects. Molecules, 29(1). https://doi.org/10.3390/molecules29010111
Fachrurrodji, F., Sidharta, B. R. A., Ariningrum, D., Suparyatmo, J. B., & Pramudianti, M. D. (2022). The effect of ginseng extract on serum interleukin-6 levels in patients with community-acquired pneumonia. Indonesian Journal of Clinical Pathology and Medical Laboratory, 28(3), 278–284. https://doi.org/10.24293/ijcpml.v28i3.1839
Hwang, K. H., Kim, H. G., Jang, K., & Kim, Y. J. (2024). Novel cultivation of six-year-old Korean ginseng (Panax ginseng) in pot: From non-agrochemical management to increased ginsenoside. Journal of Ginseng Research, 48(1), 98–102. https://doi.org/10.1016/j.jgr.2021.05.002
Hyun, S. H., Ahn, H. Y., Kim, H. J., Kim, S. W., So, S. H., In, G., ... & Han, C. K. (2021). Immuno-enhancement effects of Korean red ginseng in healthy adults: A randomized, double-blind, placebo-controlled trial. Journal of Ginseng Research, 45(1), 191–198. https://doi.org/10.1016/j.jgr.2020.08.003
Kang, S., & Min, H. (2012). Ginseng, the 'immunity boost': The effects of Panax ginseng on immune system. Journal of Ginseng Research, 36(4), 354–368. https://doi.org/10.5142/jgr.2012.36.4.354
Kim, D. H. (2012). Chemical diversity of Panax ginseng, Panax quinquefolium, and Panax notoginseng. Journal of Ginseng Research, 36(1), 1–15. https://doi.org/10.5142/jgr.2012.36.1.1
Kim, I. K., Lee, K. Y., Kang, J., Park, J. S., & Jeong, J. (2021). Immune-modulating effect of Korean red ginseng by balancing the ratio of peripheral T lymphocytes in bile duct or pancreatic cancer patients with adjuvant chemotherapy. In Vivo, 35(3), 1895–1900. https://doi.org/10.21873/invivo.12454
Lee, M. J., Choi, J. H., Kwon, T. W., Jo, H. S., Ha, Y., Nah, S. Y., & Cho, I. H. (2023). Korean red ginseng extract ameliorates demyelination by inhibiting infiltration and activation of immune cells in cuprizone-administrated mice. Journal of Ginseng Research, 47(5), 672–680. https://doi.org/10.1016/j.jgr.2023.05.001
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P., ... & Moher, D. (2009). The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: Explanation and elaboration. BMJ, 339, b2700. https://doi.org/10.1136/bmj.b2700
Park, H. Y., Lee, S. H., Lee, K. S., Yoon, H. K., Yoo, Y. C., Lee, J., ... & Park, S. R. (2015). Ginsenoside Rg1 and 20(S)-Rg3 induce IgA production by mouse B cells. Immune Network, 15(6), 331–336. https://doi.org/10.4110/in.2015.15.6.331
Ratan, Z. A., Youn, S. H., Kwak, Y. S., Han, C. K., Haidere, M. F., Kim, J. K., ... & Cho, J. Y. (2021). Adaptogenic effects of Panax ginseng on modulation of immune functions. Journal of Ginseng Research, 45(1), 32–40. https://doi.org/10.1016/j.jgr.2020.09.004
Riaz, M., Rahman, N. U., Zia-Ul-Haq, M., Jaffar, H. Z., & Manea, R. (2019). Ginseng: A dietary supplement as immune-modulator in various diseases. Trends in Food Science & Technology, 83, 12–30. https://doi.org/10.1016/j.tifs.2018.11.008
Rod-In, W., Surayot, U., You, S., & Park, W. J. (2023). Inhibitory effects of polysaccharides from Korean ginseng berries on LPS-induced RAW264.7 macrophages. PLOS ONE, 18(11), e0294675. https://doi.org/10.1371/journal.pone.0294675
Shin, B. K., Kwon, S. W., & Park, J. H. (2015). Chemical diversity of ginseng saponins from Panax ginseng. Journal of Ginseng Research, 39(4), 287–298. https://doi.org/10.1016/j.jgr.2014.12.005
Valdés-González, J. A., Sánchez, M., Moratilla-Rivera, I., Iglesias, I., & Gómez-Serranillos, M. P. (2023). Immunomodulatory, anti-inflammatory, and anti-cancer properties of ginseng: A pharmacological update. Molecules, 28(9), 3863. https://doi.org/10.3390/molecules28093863
Yoon, J., Park, B., Kim, H., Choi, S., & Jung, D. (2023). Korean red ginseng potentially improves maintaining antibodies after COVID-19 vaccination: A 24-week longitudinal study. Nutrients, 15(7), 1584. https://doi.org/10.3390/nu15071584
You, L., Cha, S., Kim, M. Y., & Cho, J. Y. (2022). Ginsenosides are active ingredients in Panax ginseng with immunomodulatory properties from cellular to organismal levels. Journal of Ginseng Research, 46(6), 711–721. https://doi.org/10.1016/j.jgr.2021.12.007
Yu, T., Yang, Y., Kwak, Y. S., Song, G. G., Kim, M. Y., Rhee, M. H., & Cho, J. Y. (2017). Ginsenoside Rc from Panax ginseng exerts anti-inflammatory activity by targeting TANK-binding kinase 1/interferon regulatory factor-3 and p38/ATF-2. Journal of Ginseng Research, 41(2), 127–133. https://doi.org/10.1016/j.jgr.2016.02.001
Zheng, S., Zheng, H., Zhang, R., Piao, X., Hu, J., Zhu, Y., & Wang, Y. (2022). Immunomodulatory effect of ginsenoside Rb2 against cyclophosphamide-induced immunosuppression in mice. Frontiers in Pharmacology, 13, 927087. https://doi.org/10.3389/fphar.2022.927087
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 VitaMedica : Jurnal Rumpun Kesehatan Umum
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
